Laurent Milot1, Maha Guindi2,3, Steven Gallinger4,5, Carol Anne Moulton4,5, Kristy Brock6, Laura Dawson6, Masoom A. Haider7,8
1Medical Imaging, Sunnybrook Health Science Center, Toronto, Ontario, Canada; 2Pathology, University Health Network, Toronto, Canada; 3Pathology, Mount Sinai Hospital, Toronto, Canada; 4General surgery, University Health Network, Toronto, Canada; 5General surgery, Mount Sinai Hospital, Toronto, Canada; 6Radiation Oncology, Princess Margaret Hospital, Toronto, Canada; 7Medical imaging, Princess Margaret Hospital, Toronto, Canada; 8Medical imaging, Mount Sinai Hospital, Toronto, Canada
Liver metastases exhibit a heterogenous structure with areas of necrosis, fibrosis and different malignant cell types. We prospectively performed high resolution MRI of the fresh ex vivo metastases of seven consecutive patient with qualitative and quantitative signal analysis of ROI defined on the pathology samples and superimposed on the MRI. Student t test was performed to assess significance of variations in signal from the different tissue types. Intra-acinar necrosis seen in colorectal metastases exhibits a specific high T1 signal and mixed T2 signal. This signal pattern is unusual for common benign liver lesions and may be helpful in the MRI diagnosis colorectal liver metastases.