Inas Khayal1,2, Trey Jalbert1, Adam ElKhaled1, Susan M. Chang3, Soonmee Cha, Sarah J. Nelson1,2
1Surbeck Laboratory of Advanced Imaging, Department of Radiology, University of California, San Francisco, San Francisco, CA, USA; 2UCSF/UCB Graduate Group in Bioengineering, University of California, San Francisco, San Francisco, CA, USA; 3Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA
Key to the interpretation of diffusion parameters as early predictors or response to therapy is a comparison between parameters in similar regions of tissue in the pre-treatment and follow-up scans. This can be problematic when there is an extensive surgical resection, which leaves a relatively small region of residual tumor and which may lead to substantial tissue shift. The goal of this study was to evaluate the differences in diffusion parameters for patients showing clinical progression or short term radiographic response using pre-, mid- and post-RT scans for patients who had their initial surgery and adjuvant therapy at UCSF.