Claudia Testa1, Raffaele Lodi1, Caterina Tonon1, Riccardo Schiavina1, Giuseppe Martorana1, Alessandro Franceschelli1, Antonietta Derrico1, Romeo Canini1, Bruno Barbiroli1
1University of Bologna, Bologna, Italy
Transrectal ultrasound biopsy (TRUS-biopsy) was performed on regions with abnormal MRI and/or 3D-MRSI for both transition (TZ) and peripheral (PZ) zones in patients suspected for prostate cancer with prior negative biopsy. Successively the relationship between 3D-MRSI and histopathological findings was analyzed. Detection rate of cancer was 40.7%; accuracy of the combination of 3D-MRSI and MRI was 0.768 for PZ and 0.822 for TZ. Flogosis remains the main cause of 3D-MRSI false positive findings (28.8%) while benign prostatic hyperplasia and post inflammatory atrophy resulted substantially negative for 3D-MRSI (2.7% and 5.1% false positive findings respectively).