Naranamangalam R. Jagannathan1, Mahesh Kumar1, Uma Sharma1, Rani Gupta Sah1
1Department of NMR and MRI Facility, All India Institute of Medcial Sciences, New Delhi, Delhi, India
In vivo proton MRS from various regions of normal breast of 24 volunteers revealed cyclic variation in the W-F value of para-areolar region during menstrual cycle. In para-areolar region, W-F value was 0.96 0.5 during proliferative phase and reduced to 0.47 0.18 and 0.40 0.29 during follicular and luteal phases. It increased to 0.77 0.6 and to 0.87 0.7 during secretory and menstrual phases. No change was observed for upper and lower quadrants. Any assessment of breast disease using W-F ratio needs careful consideration of location and effect of menstrual related variation in tissue characteristics.