Chunming Li1, Li Wang2, J. Chris Gatenby1, Adam Anderson1, John C. Gore1
1Vanderbilt University, Nashville, TN, USA; 2School of Computer Science & Technology, Nanjing University of Science and Technology, China
In this work, we propose a novel parametric method for joint image segmentation and bias field estimation for MR images. The bias field is parameterized as a linear combination of smooth basis functions. Image segmentation and bias field estimation are performed by minimizing a cost function. A desirable advantage of the proposed method is its robustness to initialization, which thereby allows fully automatic applications. Comparisons with other methods show the advantage of our method in terms of accuracy and robustness.