Yi Sui1,2, Haoyang Xing2, Theodore Claiborne2, Keith R. Thulborn, 2,3, Xiaohong Joe Zhou, 2,4
1Department of Bioengineering, University of Illinois at Chicago, Chicago, IL, United States; 2Center for Magnetic Resonance Research, University of Illinois Medical Center, Chicago, IL, United States; 3Department of Radiology, University of Illinois Medical Center, Chicago, IL, United States; 4Departments of Radiology, Neurosurgery and Bioengineering, University of Illinois Medical Center, Chicago, IL, United States
In this study, we report a spatial-spectral (SPSP) pulse that is tailored for selectively exciting the phosphocreatine (PCr) resonance at 9.4T while suppressing all other major phosphorus metabolites including inorganic phosphate and adenosine triphosphates. Using this pulse in conjunction with a RARE sequence, we have obtained PCr images from phantoms (50 mM) and the lower extremity of human volunteers in 10 minutes on a 9.4T whole-body scanner. With an in-plane spatial resolution of 7.5mm x 7.5mm, the PCr images show anatomic details with an adequate signal to noise ratio (SNR=14).