Rajakumar Nagarajan1, Whitney B. Pope1, Noriko Salamon1, Linda M. Liau2, Timothy Cloughesy3, M Albert Thomas1
Magnetic resonance spectroscopy (MRS) provides metabolic information about brain tumors complementary to what can be obtained from anatomic images. In contrast to other metabolism-based imaging techniques, MRS yields multiparametric data, does not require ionizing radiation, and can be performed in conjunction with magnetic resonance imaging studies. Magnetic resonance spectral patterns have been shown to be distinct for different tumor types and grades. Two-dimensional (2D) localized correlated spectroscopy (L-COSY) in patients with high and low grade gliomas provides better dispersion of several metabolites such as N-acetylaspartate (NAA), creatine (Cr) choline (Cho), ceramide (Cer), phosphoethanolamine (PE), glutamine/glutamate (Glx), lactate (Lac), myo-inositol (mI), taurine (Tau), etc. which has been a major difficulty in 1D MRS.