Ashish Kumar Jindal1, Matthew E. Merritt1,
Eul Hyun Suh1, Craig R. Malloy1,2, Alan Dean Sherry1,3,
Zoltan Kovacs1
1Advanced Imaging Research Center,
University of Texas Southwestern Medical Center, Dallas, TX, United States; 2Veterans
Affairs, North Texas Health Care System, Dallas, TX, United States; 3Department
of Chemistry, University of Texas at Dallas, Richardson, TX, United States
Hyperpolarization
followed by fast dissolution provides tremendous gains in SNR in both NMR and
MRI experiments, but a primary bottleneck in its application is the T1
decay of the magnetization in the liquid state. Due to its long T1,
hyperpolarized 89Y makes an excellent candidate as an in vivo imaging agent. Here we report the chemical shift
dependence upon pH for two hyperpolarized 89Y complexes and
clearly demonstrate how such complexes can be used as sensitive
spectroscopy/imaging probes to measure pH.