Stathis Hadjidemetriou1, Wilfried Reichardt1, Juergen Hennig1, Martin Buechert2, Dominik von Elverfeldt1
1Department of Diagnostic Radiology,
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the growth of kidney cysts and the eventual kidney failure in humans. A treatment for ADPKD is not yet available. Treatment development involves preclinical studies with a mouse ADPKD model. Such mice have been monitored longitudinally with high field animal MRI. In this work the mouse kidneys are segmented with an unsupervised, reliable, and reproducible method. A region of interest is identified and analyzed for its statistics and for kidney geometry. This information is incorporated into the graph cuts algorithm that delineates the kidneys. Extensive validation is presented.