Ute Goerke1, Malgorzata Marjanska1, Manda Vollmers1, Isabelle Iltis1, Pierre-Gilles Henry1, Kamil Ugurbil1
1Radiology, Center for Magnetic Resonance
For the first time, fMRI utilizing a hyperpolarized tracer 13C-labeled urea was performed. Since urea does not cross the blood-brain barrier, it is an ideal marker for perfusion changes caused by neuronal activity. The presented results were obtained in rats with forepaw stimulation. Despite the extremely low tracer concentration in the blood in gray matter, focal activated regions were robustly detected in all 13C fMRI experiments.