Rami Robert Hallac1, Yao Ding1, Qing Yuan1, Roderick W. McColl1, Jayanthi Lea2, Robert D. Sims1, Paul T. Weatherall1, Ralph P. Mason1
1Radiology, UT Southwestern Medical Center at Dallas, Dallas, TX, United States; 2Ob-Gyn Oncology, UT Southwestern Medical Center at Dallas, Dallas, TX
BOLD MRI is sensitive to tumor vascular oxygenation and may provide an indication of tumor hypoxia. We have studied normal volunteers and women with locally advanced cervical cancer to evaluate the response to breathing oxygen. Tumors showed a BOLD signal intensity response between 2.5 and 20 % at 3 T. Normal cervical tissue and uterine lining also responded, but muscle tended to show no signal enhanced in T2* weighted signal. T2* maps showed R2* = 4.233.2s-1 in normal cervix. Overall the procedure was well tolerated providing a non-invasive approach to investigating tumor oxygenation.