Michael Schr1,2, AbdElmonem M. El-Sharkawy1, Paul A. Bottomley1,3, Robert G. Weiss1,3
1Russel H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States; 2Philips Healthcare, Cleveland, OH, United States; 3Division of Cardiology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, United States
A triple repetition time saturation transfer method is applied to measure pseudo-first-order rate-constant kf of the creatine kinase reaction in the hearts of 16 patients with heart failure and 9 healthy subjects for the first time at 3T. In heart failure, kf is reduced to 65% of the normal value, in agreement with prior reports at 1.5T using a different technique. Furthermore, the intrinsic 31P T1 of phosphocreatine did not differ significantly between these subjects, possibly permitting elimination of one protocol step. The resulting two repetition time saturation transfer method, TwiST, yields the same cardiac kf measures in less time.