Kieren Grant Hollingsworth1, David Emerys
1Newcastle Magnetic Resonance Centre, Newcastle University, Newcastle upon Tyne, Tyne and Wear, United Kingdom; 2Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, Tyne and Wear, United Kingdom; 3Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, Tyne and Wear, United Kingdom
Studies of muscle metabolism in chronic fatigue syndrome (CFS) have often had contradictory results and suggested the presence of mixed phenotypes. Recent evidence has suggested that cardiac output is adversely affected in CFS. 12 female CFS/ME patients and 8 controls were recruited. Cardiac phosphorus spectroscopy, muscle exercise phosphorus spectroscopy and impedance cardiography were acquired. Cardiac PCr/ATP ratio was related to changes in cardiac index on standing and reduced PCr/ATP ratio was found to correlate with impaired oxidative function (half-times for PCr and ADP recovery). Cardiac spectroscopy was found to be useful in stratifying oxidative function in CFS.