Frederik Hengstenberg1,2, Torsten Dorniok1, Sergei Karpuk3, Jrgen Vestbo2, Rahim Rizi4, Per keson1, Peter Magnusson1, Lise Vejby Sgaard1
1Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark; 2Department of Cardiology and Respiratory Medicine, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark; 3Institute of Physics, University of Mainz, Mainz, Germany; 4Department of Radiology, University of Pennsylvania, PA, United States
There is a need for developing a more sensitive biomarker for monitoring progression of pulmonary emphysema in COPD. In this study with 20 COPD patients and 5 healthy control subjects the use of the 3He apparent diffusion coefficient (ADC) in assessing progression was investigated in a one year longitudinal study comparing ADC measurements, CT densitometry and lung function tests. In a subgroup of emphysema patients a significant increase of ADC was detected, reflecting disease progression.