James P. Sumner1, Der-Yow Chen1, Stephen Dodd1, Elizabeth Wayne1,2, Yun Chen1,3, Dragan Maric1, Alan P. Koretsky1
1National Institutes of Health, Bethesda, MD, United States; 2University of Pennsylvania, United States; 3National Institute of Standards and Technology, Boulder, CO, United States
In the adult mammals, neural progenitor cells (NPCs) migrate to the olfactory bulb and differentiate into neurons. These cells are believed to be involved in processing olfactory signals. Here we demonstrate that high resolution MRI can be utilized to evaluate the affects of odor enrichment on new neurons in the olfactory bulb with anatomical layer specificity. We found that amyl acetate enrichment resulted in the accumulation of NPCs in the mitral cell layer. This in vivo method illustrates the advantages of using high resolution anatomical imaging in combination with cell tracking.