Rajika
Maddage1, Jos P. Marques2,3, Rolf Gruetter2,4
1Laboratory of Functional and Metabolic
Imaging, Ecole Polytechnique Fdrale de Lausanne , Lausanne, Switzerland; 2Laboratory
of Functional and Metabolic Imaging, Ecole Polytechnique Fdrale de
Lausanne, Lausanne, Switzerland; 3Department of Radiology ,
University of Lausanne, Lausanne, Switzerland; 4Department of
Radiology, University of Lausanne and Geneva, Switzerland
Manganese
enhanced MRI studies have been increasingly used in animal neuroimaging
thanks to its T1 shortening properties and enhancement
specificity. The aim of this study was to quantitatively evaluate at 14.1T
the dynamic evolution of T1, T2* in
different regions of the rat brain during manganese systemic administration
and to access its impact on phase imaging. Preliminary results show
enhancement in the hippocampus and cortex in phase imaging making it a
potential tool to trace Mn2+ enrichment.