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Abstract #0325

Determination of Glomerular Filtration Rate in Cirrhotic Patients by MR Renography: Pilot Study

Pierre-Hugues Vivier1,2, Pippa Storey1, Jeff L. Zhang1, Akira Yamamoto1, Kristopher Tantillo1, Ruth P. Lim1, James S. Babb1, Henry Rusinek1, Devon John3, Lewis W. Teperman3, Kent Friedman4, Judith Benstein5, Edward Skolnik5, Vivian S. Lee1

1Radiology, NYU Langone Medical Center, New York, New-York, United States; 2LITIS Laboratory EA4108, School of Medicine and Pharmacy, Rouen, France; 3Transplant Clinic, NYU Langone Medical Center, New York, New-York, United States; 4Nuclear Medicine, NYU Langone Medical Center, New York, New-York, United States; 5Nephrology, NYU Langone Medical Center, New York, New-York, United States


Glomerular filtration rate (GFR) assessment based on creatinine formulas is highly inaccurate in cirrhotic patients, despite its utmost importance. We prospectively investigated the feasibility, accuracy, precision and reproducibility of MR-GFR measurements in 20 cirrhotic patients undergoing routine liver MRI, using a protocol that added less than 10 additional minutes and 3 mL gadoteridol. Urinary clearance of 99mTc-DTPA served as reference GFR. MR-GFR values were more accurate and precise than creatinine-based GFR values. Reproducibility was comparable to the reference method.