Detection of Myo-Inositol In-Vivo Using MR Chemical Exchange Saturation Transfer Imaging (MICEST)

Mohammad Haris¹, Kejia Cai¹, Anup Singh¹, Feliks Kogan¹, Walter Witschey¹, Hari Hariharan¹, Ravinder Reddy¹

In the current study, we demonstrated the mapping of Myo-inositol (MI) in human brain at 7T by exploiting chemical exchange saturation transfer (CEST) of labile hydroxyl proton (-OH) on the MI. The Z-spectrum of MI showed an asymmetry around~0.625ppm downfield to the bulk water resonance. The CEST imaging on healthy human brain clearly shows the distribution of MICEST contrast in gray and white matter regions and negligible contrast from cerebrospinal fluid.