Eric Edward Sigmund1, Linda Moy1, Gene Cho1, Sungheon Kim1, Myra Finn1, Jens Hesselberg Jensen1, Melanie Moccaldi1, Daniel Sodickson1, Robert Schneider2, Silvia Formenti3
1Radiology, New York University Langone Medical Center, New York, NY, United States; 2Microbiology, New York University Langone Medical Center, New York, NY, United States; 3Radiation Oncology, New York University Langone Medical Center, New York, NY, United States
Diffusion-weighted imaging (DWI) is playing an increasing important role in breast cancer lesion characterization, most commonly marking restricted diffusion in tumor cellularity. Intravoxel incoherent motion (IVIM) MRI is a DWI variant ideally providing markers not only of cellularity, but also tumor vascularity and blood velocity. In this study we acquired IVIM data in N=25 breast cancer patients at 3 T and compared these markers with contrast-enhanced MRI and biopsy diagnosis. Robust quantification of the IVIM parameter set clearly differentiated lesions from the weakly perfused normal fibroglandular tissue and may be helpful for future quantitative lesion grading.