Julien Valette1,2, Boucif Djemai2, Franoise Geffroy2, Mohamed Ahmed Ghaly2, Fawzi Boumezbeur2, Denis Le Bihan2, Franck Lethimonnier2
1CEA-MIRCen, Fontenay-aux-Roses, France; 2CEA-NeuroSpin, Gif-sur-Yvette, France
Diffusion-weighted (DW) spectroscopy is a unique tool for probing the intracellular compartment in vivo. As far as we know, the apparent diffusion coefficient (ADC) of metabolites has never been reported in the mouse brain. In this preliminary work, the ADC of six metabolites is measured in a mouse brain for the first time, using an original DW-LASER sequence. In addition, measurements are performed in a Human U87-MG glioblastoma induced in the same animal, showing a dramatic increase in the ADC of choline compounds, which might be ascribed to lactacidosis-induced cell swelling.