Yang Guo1, Ning Jin1,2, Rachel Klein1, Guang-Yu Yang3, Reed Omary1,2, Andrew Larson1,2
1Department of Radiology, Northwestern University, Chicago, IL, United States; 2Department of Biomedical Engineering , Northwestern University, Chicago, IL, United States; 3Department of Pathology, Northwestern University, Chicago, IL, United States
Angiogenesis is fundamental for tumor growth, invasion and metastasis. Non-invasive methods to monitor tumor neo-vascular changes during tumor progression and/or in response to anti-angiogenic therapy may be critical. The purpose of our study was to investigate the relationship between gas-challenge (GC)-BOLD response and degree of tumor angiogenesis during tumor progression in rodent hepatoma model. A positive correlation was found between GC-BOLD response and tumor microvessel density and a negative correlation was between GC-BOLD response and tumor size. GC-BOLD MRI may offer the potential to serve as a non-invasive method for evaluating angiogenesis and monitoring anti-angiogenic therapy response in hepatic tumors.