Karen Catherin Briley-Saebo1, Sung Kee Ryu2, Simone Green2, Venkatesh Mani3, Stephen Dickson3, Sotirios Tsimikas2, Zahi A. Fayad3
1Radiology and Gene and Cell Medicine, Mount Sinai School of Medicine, NY, United States; 2Vascular Medicine, University of California San Diego, La Jolla, CA, United States; 3Radiology, Mount Sinai School of Medicine, NY, United States
Oxidized low-density lipoproteins (OxLDL) play a major role in plaque progression. Although OxLDL-targeted gadolinium micelles have been used for in-vivo detection of intraplaque macrophages, safety issues may limit clinical utility. The aim of the current study was to evaluate the in-vivo efficacy of oxLDL-targeted iron oxides. Small (<25nm) and large (>50nm) oxLDL-targeted particles were administered (4-mgFe/kg) to ApoE-/- mice. Imaging was performed 24 hours p.i. at 9.4T. Significant enhancement (R2*>50%) was observed for the small oxLDL-targeted particles. Untargeted and large formulations exhibited limited enhancement. This study suggests that small OxLDL-targeted particles may allow for safe detection of foam cells.