Sylvie Girard1, Luc Tremblay2, Guillaume Sebire1, Martin Lepage2
1Pediatric, Universite de Sherbrooke, Sherbrooke, Qc, Canada; 2Radiobiology, Universite de Sherbrooke, Sherbrooke, Qc, Canada
Perinatal inflammation affects brain development and could modify the permeability of the developing blood-brain barrier (BBB). This can have an impact on the accessibility of both inflammatory mediators and therapeutics drugs, to the brain. This study aimed at evaluating the postnatal variations of permeability of the developing BBB. Using a contrast agent, we observed a decreased permeability of the BBB during normal development. However, prenatal exposure to a pro-inflammatory agent led to a region-specific increased permeability during the first 30 days after birth. This provides new insights into the mechanisms explaining the vulnerability to aggressions in newborns causing brain damage.