Paul Michael Walker1,2, Gilles Crhange3, Sbastien Parfait2, Alexandre Cochet1, Philippe Maingon3, Luc Cormier1, Franois Brunotte1,2
1University Hospital of Dijon, Dijon, France; 2LE2I, University of Burgundy, Dijon, France; 3Radiotherapy Department, CGFL, Dijon, France
Although, it is common in MRSI to use a Choline/Citrate ratio when evaluating PCa, the use of citrate (Cit) as a reference is questionable in the context of treatment such as hormonotherapy and radiotherapy, because Cit levels fall very sharply even in non-cancerous tissue. We have proposed an absolute quantification method at 3T and we observed significantly higher Cit in normal PZ than in CG tissue. However, in PCa, reductions in Cit were not accompanied by important increases in tCho, suggesting increases in tCho/Cit are primarily due to loss of Cit and not to a sharp rise in tCho.