Bradley J. MacIntosh1,2, Lars Marquardt3, Ursula G. Schulz3, Peter M. Rothwell3, Peter Jezzard2
1Imaging & Brain Sciences, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; 2Clinical Neurology, FMRIB Centre, Oxford, OXON, United Kingdom; 3Clinical Neurology, Stroke Prevention Research Unit, Oxford, OXON, United Kingdom
Arterial spin labeling is a versatile perfusion MRI technique and recent studies have shown clinical merit. One clinical arena that is under-investigated is perfusion profiles in patients with vertebral or basilar artery (VBA) stenosis. The arrival of the magnetic spin tracer is expected to be delayed in these patients therefore a multiple inflow 3D-GRASE-PASL implementation is used to estimate cerebral blood flow (CBF) and the arterial arrival time (AAT). Patients with presumed severe VBA disease (N=4), on the basis of their clinical history, showed significantly prolonged AAT (P<0.01) and reduced CBF (P=0.08) when compared to patient with presumed no VBA disease (N=10).