Michael A. Chappell1,2, Adrian R. Groves1, Bradley J. MacIntosh1,3, Manus J. Donahue1, Peter Jezzard1, Mark W. Woolrich1
1FMRIB Centre, University of Oxford, Oxford, United Kingdom; 2Institute of Biomedical Engineering, University of Oxford, Oxford, United Kingdom; 3Imaging Research, Sunnybrook Research Institute, Toronto, Canada
The partial voluming of gray matter (GM), white matter (WM) and CSF in ASL leads to underestimates of GM CBF. Here a correction strategy is proposed for multi-TI ASL as part of the kinetic curve model fitting analysis. The method exploits the differences in kinetics between GM and WM and also employs constraints based on partial volume estimates of the tissue types. The proposed method is shown to provide GM CBF estimates corrected for partial voluming while preserving details within the GM CBF image.