R. Adam Horch1,2, Jeffery
1Vanderbilt University Institute of
Imaging Science, Vanderbilt University, Nashville, TN, United States; 2Biomedical
Engineering, Vanderbilt University, Nashville, TN, United States; 3VA
Tennessee Valley Healthcare System, Vanderbilt University, Nashville, TN,
United States; 4Orthopaedics & Rehabilitation Medicine,
Vanderbilt University, Nashville, TN, United States; 5Radiology
and Radiological Sciences, Vanderbilt University, Nashville, TN, United
States
The
complex 1H NMR behavior of human cortical bone can be attributed
to distinct microanatomical proton environments in the bone matrix and pore
spaces. Herein, the multiexponential 1H transverse relaxation of
human cortical bone was studied in conjunction with numerous mechanical
properties relevant to overall bone integrity. Numerous NMR-mechanical
correlations were observed, indicating links between cortical bone proton
pools and bone health. These correlations allow bone mechanical properties to
be predicted from NMR measurements and provide a contrast mechanism that MRI
protocols could exploit as a novel bone health diagnostic.