Magnus
Karlsson1,2, Pernille Rose Jensen1,2, Rene in 't Zandt1,3,
Georg Hansson1, Anna Gisselsson1,3, Jensen Duus4,
Sebastian Meier4, Mathilde Hauge Lerche1,2
1Imagnia AB, Malmoe, Sweden; 2Albeda
Research Aps, Valby, Denmark; 3Eijdo Research AB, Malmoe, Sweden; 4Carslberg
Research Center, Valby, Denmark
Hyperpolarized
13C magnetic resonance (MR) spectroscopy has in many cases the
potential to deliver the sensitivity and detailed spectral information to
report on the chemical fate of tracer molecules in different tissues. In a
preclinical study we here show that -ketoisocaproic acid (KIC) can be used
to assess molecular signatures of tumors using hyperpolarized MR
spectroscopy. KIC is metabolized to leucine by the enzyme branched-chain
aminotransferase (BCAT), which is a putative marker for metastasis and a
target of the proto-oncogene c-myc.