Hamied Ahmad Haroon1,2, Richard J. Binney,
2,3, Geoff J M Parker1,2
1Imaging Science and Biomedical Engineering,
School of Cancer and Imaging Sciences, The University of Manchester,
Manchester, England, United Kingdom; 2The University of Manchester
Biomedical Imaging Institute, The University of Manchester, Manchester,
England, United Kingdom; 3Neuroscience and Aphasia Research Unit,
School of Psychological Sciences, The University of Manchester, Manchester,
England, United Kingdom
Model-based
residual bootstrapping applied to constrained spherical deconvolution
analysis of HARDI provides probabilities of observing n fiber orientations in every voxel of the brain. We hypothesized
that the distribution of these probabilities for each n within cortical and subcortical regions would reflect the
varying underlying neural microstructural complexity associated with each. We
show evidence supporting this hypothesis and show consistency between
hemispheres and amongst a small group of healthy subjects. This may offer
non-invasive sensitivity to cortical cytoarchitecture that may be useful in
cortical parcellation and in the identification of cortical lesions.