Khader M. Hasan1, Indika S. Walimuni1, Humaira Abid1, Larry A. Kramer1, Richard E. Frye2, Jack M. Fletcher3, Linda Ewing-Cobbs2
1Diagnostic and Interventional Imaging, University of Texas Health Science Center at Houston, Houston, TX, United States; 2Pediatrics, UTHSC, Houston, TX, United States; 3Psychology, University of Houston, Houston, TX, United States
In this work, we report for the first time a comprehensive account of the macro and microstructure of these structures using a large cross-sectional healthy cohort across the healthy lifespan (N=281 males and females aged 6-68 years). We demonstrate using a validated novel DTI and atlas-based tissue segmentation approach that the MRI microstructural correlates of volume decrease of these structures bilaterally, in both men and women are a T2 relaxation that follows a U curve that is commensurate with a fractional ansiotropy increases with age and a U curve mean diffusivity. A strong correlation between T2 and mean, radial and axial diffusivities is also noted. The interplay between T2 relaxation and DTI metrics was also examined.