Maria Fatima Falangola1,2, Caixia Hu1, Vitria Adisetiyo1, Ali Tabesh1, Wende R. Gelb1, Jens H. Jensen1, Joseph A. Helpern1,2
1Radiology, New York University Langone Medical Center, New York, NY, United States; 22Center for Advanced Brain Imaging, Nathan Kline Institute, Orangeburg, NY, United States
The thalamus is a major subcortical relay station that filters incoming primary sensory input and modulates processed cortical information through reciprocal cortico-thalamic connections. Therefore, it is a key region for fronto-temporal communication and is crucial for modulating emotion and cognition in humans. We applied Diffusional Kurtosis Imaging (DKI) to investigate the age-related non-Gaussian patterns of microstructure change in the thalamus. The data presented here suggest that non-Gaussian metrics, particularly MK and Kra are the most useful in detecting developmental changes in the thalamus.