Llewellyn Jalbert1, Adam Elkhaled1,
Radhika Srinivasan1, Hikari Yoshihara1, Colleen Cloyd1,2,
Gabriela Bourne1, Susan M. Chang3, Soonmee Cha1,
John Kurhanewicz1,4, Sarah J. Nelson1,4
1Department of Radiology &
Biomedical Imaging, University of California - San Francisco, San Francisco,
CA, United States; 2School of Pharmacy, University of California -
San Francisco, San Francisco, CA, United States; 3Department of
Neurological Surgery, University of California - San Francisco, San
Francisco, CA, United States; 4Department of Bioengineering &
Therapeutic Sciences , University of California - San Francisco, San
Francisco, CA, United States
Proton
High Resolution Magic Angle Spectroscopy (1H HR-MAS) has offered
new insight into tumor physiology that may be valuable in understanding the
process of glial tumorigenesis.
Fifty-four patients w/ pathologically confirmed WHO Grade 2 recurrent
glioma underwent pre-surgical MRI / 3D MRSI, image guided biopsy excision,
and 1H HR-MAS analysis.
Patients whose tumors had histologically upgraded to WHO Grade 3
exhibited greater concentrations of PC (p=.008), GPC (p=.049), glucose
(p=.002), and total choline (p=.01). Our 1H HR-MAS results may
contribute in identifying low-grade glioma patients whose tumors have become
more aggressive and assist in treatment planning and selection.