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Abstract #0618

Correlation of DTI Metrics with Proliferation Index and Survival Analysis in Glioblastomas

Sona Saksena1, Rajan Jain1, Jayant Narang1, Lonni Schultz2, David Hearshen1, Lisa Scarpace3, Norman Lehman4, Tom Mikkelsen3

1Radiology, Henry Ford Hospital, Detroit, MI, United States; 2Biostatistics and Research Epidemiology, Henry Ford Hospital, Detroit, MI, United States; 3Neurosurgery, Henry Ford Hospital, Detroit, MI, United States; 4Pathology, Henry Ford Hospital, Detroit, MI, United States


DTI data were acquired from thirty-four patients with glioblastomas with an aim to retrospectively correlate the changes in fractional anisotropy (FA) and apparent diffusion coefficient (ADC) with degree of proliferation index determined histologically and patient survival analysis. We found that patients with ADCmin (0.6) and FAmean (0.2) had lower progression free survival rate or poorer prognosis. In conclusion, DTI can be used as a clinical prognostic biomarker for disease free survival in patients with glioblastomas and might be useful for planning initial treatment strategy in these patients.