Egbert JW Bleeker1, Matthias JP van Osch1, Alan Connelly2,3, Mark A. van Buchem1, Andrew G. Webb1, Fernando Calamante2,3
1C.J.Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands; 2Brain Research Institute, Florey Neuroscience Institutes (Austin), Melbourne, Australia; 3Department of Medicine, University of Melbourne, Melbourne, Australia
The current criteria for AIF selection algorithms determine correct measurements based on the shape of the first passage. However, this shape can be altered by partial volume effects, which often occur in AIF measurements due to the relatively low spatial resolution. A new criterion is proposed, based on tracer kinetic theory, that uses the additional information of the steady state to detect partial volume effects in the AIF measurement. This study shows that the proposed criterion should be a valuable addition to the current selection criteria.