Michael
Ingrisch1, Steven Sourbron1, Dominik Morhard, Lisa-Ann
Gerdes2, Tania Kmpfel2, Reinhard Hohlfeld2,
Maximilian F. Reiser, Christian Glaser
1Josef Lissner Laboratory for
Biomedical Imaging, Institute of Clinical Radiology, Ludwig Maximilian
University, Munich, Germany; 2Institute for Clinical
Neuroimmunology, Ludwig Maximilian University, Munich, Germany
We
evaluate the feasibility of a 3D DCE-MRI measurement for the absolute
quantification of perfusion and permeability in Multiple Sclerosis and
present initial results. 19 patients were examined, perfusion and
permeability were quantified with 2-compartment models in white matter,
non-enhancing(NE) and contrast-enhancing(CE) lesions. The results show clear
separation of WM and CE lesions in the permeability estimates; WM perfusion
was lower than standard values from literature. The parameter variation in
NE- and CE-lesions was relatively large, suggesting a potential for lesion
characterization and monitoring of the effects of disease-modifiying drugs.