Parastou Foroutan1, Katherine J. Schweitzer2, Dennis W. Dickson3, Daniel F. Broderick4, Uwe Klose5, Daniela Berg6, Zbigniew K. Wszolek2, Samuel C. Grant1
1Chemical & Biomedical Engineering, The Florida State University, Tallahassee, FL, United States; 2Department of Neurology, Mayo Clinic Florida, Jacksonville, FL, United States; 3Department of Neuroscience, Mayo Clinic Florida, Jacksonville, FL, United States; 4Department of Radiology, Mayo Clinic Florida, Jacksonville, FL, United States; 5Department of Radiology, Section for Experimental ZNS Imaging, University hospital Tuebingen, Tuebingen, Germany; 6Hertie Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany
The first MRM evaluations of human tissue (Alzheimer/Parkinson related pathology) at 21.1 T, the highest magnetic field available for MRI, are presented. Quantitative analysis of relaxation proved very sensitive in identifying control versus pathological tissue, while parametric mapping demonstrated the potential for categorizing severity. Generally, neurodegeneration appeared more pervasive than expected, extending well beyond the regions normally considered to be affected by either Alzheimers or Parkinsons disease alone. As a pathological tool, MRM has potential to elucidate the extent and severity of such neurodegeneration, and hopefully, may improve the diagnostic capabilities of MRI as higher magnetic fields become available.