Audrey Peiwen Fan1, Thomas Benner2, Divya S. Bolar3, Bruce R. Rosen2,3, Elfar Adalsteinsson, 1,3
1Electrical Engineering and Computer Science, MIT, Cambridge, MA, United States; 2Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, United States; 3Health Sciences and Technology, Harvard-MIT, Cambridge, MA, United States
The cerebral metabolic rate of oxygen (CMRO2) is an important indicator for brain function and disease, including stroke and tumor. CMRO2 can be quantified from measurements of venous oxygen saturation (Yv) and cerebral blood flow (CBF) in cerebral veins. Bulk susceptibility measurements based on gradient-echo phase maps has been used to estimate Yv in vivo at 3T. Challenges of this technique include partial volume effects, phase wrapping, and background susceptibility gradients. Here we combine phase-based measurements of Yv with ASL measurements of CBF to quantify CMRO2 in cerebral vessels at 3T. Further, we extended estimates of Yv to 7T, achieving a 1/5 reduction in voxel size. The improved spatial resolution allows examination of smaller vessels more indicative of regional brain function. Future work includes extending the method to estimate CMRO2 at 7T.