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Abstract #0717

Hippocampal Blood Flow and Vascular Reactivity in Normal Aging

Henry Rusinek1, Lidia Glodzik2, Miroslaw Brys3, Francois Haas4, Kellyanne Mcgorty1, Qun Chen1, Mony J. de Leon2

1Radiology, New York University School of Medicine, New York, NY, United States; 2Psychiatry, New York University School of Medicine, New York, NY, United States; 3Neurology, New York University School of Medicine, New York, NY, United States; 4Medicine, New York University School of Medicine, New York, NY, United States


Hippocampal blood flow and vascular reactivity were measured in 34 normal subjects aged 26-92 years using pulsed ASL with segmented TrueTFISP readout. Test-retest studies indicate reproducibility averaging 3.6 ml/100g/min (5.4%). Hippocampal flow averaged 61.29.0 ml/100g min, with no age effect. The cortical flow averaged 57.210.4 ml/100g min and there was a significant linear relationship with age. Mild hypercapnia resulted in a significant CBF increase in all brain tissue. The flow response was 18.012.2 in neocortex and 14.110.8 in the hippocampus. The cortical flow response among the women was significantly larger than in men, confirming numerous prior studies.