Hsiao-Ying Wey1,2, Fang Du1,
Ai-Ling Lin1, Yen-Yu I. Shih1, Saaussan Madi3,
Peter T. Fox1,2, Pradeep M. Gupte4, Timothy Q. Duong1,2
1Research Imaging Institute, UT Health
Science Center at San Antonio, San Antonio, TX, United States; 2Radiology,
UT Health Science Center at San Antonio, San Antonio, TX, United States; 3Bruker
Biospin MRI, Inc., Billerica, MA, United States; 4Rockland
Technimed Ltd., Airmont, NY, United States
Cerebral
metabolic rate of oxygen (CMRO2) is an important physiological parameter
associated with normal brain and disease state. The unique characteristic of 17oxygen
makes 17O MRI a valuable tool for CMRO2 quantification.
Direct 17O measurement suffers from low spatiotemporal resolution
and clinical practicability compared to indirect method, although the
quantification is more straightforward. This study demonstrates the
feasibility of indirect T1ρ-weighted 17O detection with 17O/PFC
blood substitute injection in normal and physiologically modulated
(hypothermia and ischemic stroke) rats at ultra-high field.