Mellisa Damodaram1,2, Lisa Story1,2, Prachi Patkee1, Abhilasha Patel1,2, Amy McGuinness1, Joanna Allsop1, Sailesh Kumar, 2, Jo Hajnal1, Mary Rutherford1
1Robert Steiner MRI Unit, Hammersmith Hospital, Imperial College London, London, United Kingdom; 2Imperial College Healthcare Trust, London, United Kingdom
Fetal intrauterine growth restriction is a significant problem that often results in iatrogenic premature delivery of the fetus. These children may have neurodevelopmental delay and exhibit problems that cannot be explained by the complications of prematurity alone. Little is known about the exact neurostructural deficiencies that arise as a result of intrauterine growth restriction, and MR studies have been limited by difficulties overcoming the inherent problem of fetal motion. We describe a technique to conduct 3D reconstruction of the fetal brain that enables volumetric analysis of the whole brain and cerebellum in both normally grown and growth restricted fetuses.