Joshua S. Shimony1, Jason Hill1, John Harwell1, Tim Coalson1, Dierker Donna1, Terrie Inder1, David Van Essen1, Jeff J. Neil1
A variety of measures have been proposed to evaluate cortical folding, many of which are based on the mathematical quantity of curvature. We obtained MRI data from premature infants at <27, 30-31, 34-35, and 38-39 wks postmenstrual age (PMA). We evaluated how 17 cortical folding measures change with increasing PMA. There was considerable disparity in the sensitivity of the measures to cortical maturation, though a subset increased in a monotonic and predictable fashion, making them suitable for evaluation of brain development.