Ashok Panigrahy1,2, Marvin D. Nelson1, Floyd H. Gilles3, Lisa Paquette4, Istvan Seri4, Stefan Bluml1,5
1Department of Radiology, Childrens Hospital Los Angeles, Los Angeles, CA, United States; 2Department of Radiology, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, United States; 3Department of Neuropathology, Childrens Hospital Los Angeles, Los Angeles, CA, United States; 4Division of Neonatology, Childrens Hospital Los Angeles, Los Angeles, CA, United States; 5Rudi Schulte Research Institute, Santa Barbara, CA, United States
In this study, we compare age-dependent changes of metabolites using quantitative MR spectroscopy in white and grey matter of premature neonates without brain injury with normal biochemical maturation in age-matched term neonates. There are subtle but significant differences in the biochemical maturation of white matter in premature infants with normal conventional MR imaging when compared to control term infants. The observations suggest accelerated white matter development in the premature brain possibly from increased sensory-motor stimulation in the extra-uterine environment or possibly a reparative response to subtle brain injury (i.e. possibly related to sepsis induced white matter injury).