Marine Beaumont1, Marc G. DuVal2, Yasir Loai3, Walid A. Farhat3, George K. Sndor2, Hai-Ling Margaret Cheng1,4
1The Research Institute and Diagnostic Imaging, The Hospital for Sick Children, Toronto, Ontario, Canada; 2Department of Oral and Maxillofacial Surgery, University of Toronto, Toronto, Ontario, Canada; 3Division of Urology, The Hospital for Sick Children, Toronto, Ontario, Canada; 4Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
Tissue repair plays a key role in successful tissue regeneration and involves various simultaneous processes. In bone regeneration, bone growth in a defect occurs only in the absence of early fibrous scar formation or collapse of surrounding tissues into the defect. In this study, a tissue-engineered construct is inserted into a defect in the rabbit calvarium to provide a 3-dimensional resorbable scaffold that maintains a space for bone growth. Multicomponent T2 measurements are performed to characterize and differentiate tissue repair from normal construct resorption.