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Abstract #0859

Post-Ischemic Stenosis and Reperfusion Studied by Dynamic 31P MRS and Functional Imaging

Albrecht Ingo Schmid1,2, Martin Andreas3, Martin Meyerspeer2,4, Ewald Moser1,4, Michael Wolzt1

1Dpt. of Clinical Pharmacology, Medical University of Vienna, Wien, Austria; 2MR Center of Excellence, Medical University of Vienna, Wien, Austria; 3Department of Cardiac Surgery, Medical University of Vienna, Wien, Austria; 4Center of Biomedical Engineering and Physics, Medical University of Vienna, Wien, Austria


Post-ischemic stenosis is a common clinical finding, yet rarely studied by NMR. 31P MRS and BOLD sensitive EPI was measured (two days) in 11 male subjects, with and without 5min stenosis (cuff at 30mmHg below cystolic pressure) following 20min cuff (thigh), the last two minutes performing plantar flexion. During stenosis pH and PCr remained at post-ischemic levels, BOLD signal declined further. In conclusion, stenosis is a state in which oxygen supply is insufficient to start PCr recovery.