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Abstract #0868

Effect of Cholecalciferol Supplementation on Muscle Strength in Healthy Volunteers with Low Serum 25(OH)D: A Double Blind Randomized Placebo Controlled Trial

Rajat Gupta1, Uma Sharma2, Nandita Gupta1, U Singh3, Randeep Guleria4, Naranamangalam R. Jagannathan2, Ravinder Goswami1

1Department of Endocrinology, All India Institute of Medical Sciences, New Delhi, Delhi, India; 2Department of NMR & MRI Facility, All India Institute of Medical Sciences, New Delhi, Delhi, India; 35Department of Physical Medicine and Rehabilitation, All India Institute of Medical Sciences, New Delhi, Delhi, India; 4Department of Medicine, All India Institute of Medical Sciences, New Delhi, Delhi, India


Effects of six months cholecalciferol and calcium supplementation was investigated on the skeletal muscle strength and muscle energy metabolism using 31PMRS in healthy volunteers with low serum 25(OH)D in a double blind randomized placebo controlled trial. At six months, 25(OH)D levels, hand grip strength, gastrosoleus muscle strength, distance covered during six minute walk were significantly higher in cholecalciferol compared to placebo group (p=0.001). There were no significant differences in MIP, MEP and PCr/Pi ratio in the two groups at six months. Thus, improvement in muscle strength could be due to factors other than change in muscle energy metabolism.