Alexander
Gussew1, Marko Erdtel1,2, Reinhard Rzanny1,
Juergen R. Reichenbach1
1Medical Physics Group, Department of
Diagnostic and Interventional Radiology, Jena University Hospital, Jena,
Germany; 2University of Applied Sciences Jena, Jena, Germany
This
work describes in vitro and in vivo validation of absolute
quantitation of 1H-MRS brain data with respect to heterogeneous
tissue distributions within the MRS-volume. NAA concentrations were estimated
from metabolite and water spectra obtained from MRS-voxels containing
different metabolite and water
concentrations and were compared with nominally adjusted values. The maximal
error was 4% compared to 41%, if the tissue heterogeneity was neglected. Inter-individual
distributions of NAA-, Cr- and tCho-concentrations obtained in insular cortex
of volunteers had twice less scatter when taking into account the
heterogeneous tissue composition in the voxel.