Alexander Gussew1, Marko Erdtel1,2, Reinhard Rzanny1, Juergen R. Reichenbach1
1Medical Physics Group, Department of Diagnostic and Interventional Radiology, Jena University Hospital, Jena, Germany; 2University of Applied Sciences Jena, Jena, Germany
This work describes in vitro and in vivo validation of absolute quantitation of 1H-MRS brain data with respect to heterogeneous tissue distributions within the MRS-volume. NAA concentrations were estimated from metabolite and water spectra obtained from MRS-voxels containing different metabolite and water concentrations and were compared with nominally adjusted values. The maximal error was 4% compared to 41%, if the tissue heterogeneity was neglected. Inter-individual distributions of NAA-, Cr- and tCho-concentrations obtained in insular cortex of volunteers had twice less scatter when taking into account the heterogeneous tissue composition in the voxel.