1Laboratory of Functional and Metabolic
Imaging, Ecole Polytechnique Fdrale de Lausanne, Lausanne, Switzerland; 2Departments
of Radiology, Universities of Lausanne and Geneva, Switzerland
Phosphorus
saturation transfer technique is sensitive to experimental imperfections such
as partial direct saturation of the measured peak, incomplete saturation of
the other peak under exchange and a problematic localization, which is
usually done by an active volume of a surface coil used as a transceiver. In
our study we compared the PCr <> γ-ATP saturation transfer
experiment using 1D ISIS localization combined or not combined with outer
volume saturation. We observed a contaminating component from muscles in the
PCr signal when using the 1D