Congju Chen1, David J. Brenner2, Truman R. Brown1
1Department of Radiology, Columbia University, New York, NY, United States; 2Center for Radiological Research, Columbia University, New York, NY, United States
In previous work we have identified a dozen biomarkers in urine from radiation-exposed mice by NMR spectroscopy. The mouse model allowed us to understand the effect of key parameters such as dose, time post-exposure on the urinary biomarkers. To validate these biomarkers in humans, in this work we investigate urinary biomarkers associated with radiation exposure in acute leukemia patients undergoing a series of total body irradiation treatments in preparation for a hematopoietic stem cell transplant. The results indicated that besides some common urinary radiation biomarkers from both mice and human, there are some unique radiation signatures in human urine.