Changho Choi1, Aditya Patel1
1Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States
Serine (Ser) in human brain, which has coupled proton resonances at 3.98, 3.94, and 3.83 ppm, is difficult to measure because of its relatively low concentration (~0.5 mM) and the spectral overlap with the creatine (Cr) 3.92 ppm resonance. Constant-TE difference editing strategies for detection of Ser at 3T have been explored. Echo time dependence of the Ser multiplet was investigated, with density-matrix simulation, for point-resolved spectroscopy and triple refocusing. The Ser multiplets in sub- and difference-spectra were in good agreement between simulation and phantom experiments. In vivo feasibility of the difference editing methods is discussed with results from a phantom with physiological concentrations of Ser and Cr.