Kaung-Ti Yung1, Chenguang Zhao1, Weili Zheng1, Manel Martinez-Ramon2, Andre van der Kouwe3, Stefan Posse1,4
1Neurology, University of New Mexico School of Medicine, Albuquerque, NM, United States; 2Dept. of Signal Processing and Communications, Universidad Carlos III de Madrid, Madrid, Spain; 3Radiology, Massachusetts General Hospital, Boston, MA, United States; 4Electrical and Computer Engineering, University of New Mexico, Albuquerque, NM, United States
Manual placement of outer volume suppression (OVS) slices in short TE proton MR spectroscopic imaging (MRSI) is time consuming and prone to human error. Here, we introduce an atlas-based approach to optimally positions both the 3D MRSI slab and up to 16 OVS slices in a subjects head using affine transformation of MRSI slab and OVS slice positions that are optimally placed in MNI space. In vivo 3D short TE (11 ms) Proton-Echo-Planar-Spectroscopic-Imaging (PEPSI) demonstrates consistent spectral quality with the MRSI volume and comparable lipid suppression for automatic and manual OVS placement, which is desirable for clinical research studies.